A biological age test can offer a different view of aging than your birthday does, but the tests here do not all measure the same thing. My leading pick for a broad set of epigenetic metrics is TruAge Complete Collection, which reports several DNA-methylation measures, including Dunedin PACE. SelfDecode Healthy Aging and Longevity is a better match for people who want genetic insights and a substantial set of recommendations without a blood sample, while Hundred Health takes a lab-biomarker route and adds physician review and app-based tracking.
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The main choice is between tests that estimate age through DNA methylation, tests that examine inherited genetic variants, and lab panels that measure present-day health markers related to aging. These approaches answer different questions, so I would not treat their results as interchangeable or expect one test to establish a diagnosis. Sample collection, report depth, medical context, and the ability to repeat a test all shape which option makes sense. My ranking favors clear biological-age relevance, useful distinctions between reported measures, and practical value for a person deciding what to do with the results.
Key Takeaways
- TruAge is the strongest fit here for buyers who want multiple DNA-methylation age measures, including Dunedin PACE and telomere-related reporting.
- SelfDecode uses a cheek swab rather than blood and emphasizes genetic variants plus 50 personalized wellness recommendations, not a direct methylation-age panel.
- Aeternum uses saliva and DNA methylation, making it a simpler sample-format alternative to TruAge, though the supplied details describe fewer separate metrics.
- Hundred Health measures more than 100 health biomarkers and adds physician review, but it is not presented as a dedicated DNA-methylation clock test and has regional appointment exclusions.
- PlexusDX offers the widest stated report count at more than 150, but its listed information does not specify turnaround time or explain the biological-age calculation in detail.
| TruAge Complete Collection |  | Best Overall for Multiple Epigenetic Age Measures | Sample type: Fingertip blood spot | Analysis: DNA methylation markers | Named reports: Epigenetic age, telomere length, Dunedin PACE, intrinsic and extrinsic age, immune-cell ratios, and weight-loss response | VIEW LATEST PRICE | See Our Full Breakdown |
| SelfDecode Healthy Aging and Longevity At-Home DNA Test |  | Best Needle-Free Genetic Wellness Report | Sample collection: At-home cheek swab | Laboratory: CLIA-certified lab | Analysis: AI analysis across 200 million genetic variants and peer-reviewed research | VIEW LATEST PRICE | See Our Full Breakdown |
| Aeternum DNA Biological Age Test Kit |  | Best Saliva-Based Methylation Test for Beginners | Test type: At-home DNA-methylation test | Sample: Saliva | Analysis: DNA methylation markers | VIEW LATEST PRICE | See Our Full Breakdown |
| Hundred Health Comprehensive Lab Test with 100+ Biomarkers |  | Best for Physician-Reviewed Health Context | Biomarkers: More than 100 | Health areas: Heart and metabolic health, hormones, inflammation, nutrients, stress, and aging | App features: Combines lab results, medical records, wearable data, and recommendations | VIEW LATEST PRICE | See Our Full Breakdown |
| PlexusDx Methylation and Longevity Genetic Test |  | Best for Broad Genetics-Related Longevity Reports | Test type: At-home DNA test | Reports: More than 150 DNA reports | Genetic analysis: Over 200 million genetic variants | VIEW LATEST PRICE | See Our Full Breakdown |
| biological age test | Analysis |
|---|---|
| TruAge Complete Collection | DNA methylation markers |
| SelfDecode Healthy Aging and L | AI analysis across 200 million genetic variants and peer-reviewed research |
| Aeternum DNA Biological Age Te | DNA methylation markers |
| Hundred Health Comprehensive L | — |
| PlexusDx Methylation and Longe | — |
More Details on Our Top Picks
TruAge Complete Collection
TruAge Complete Collection earns my top spot because its stated report suite gives buyers several ways to look at aging, rather than presenting a single number as the whole story. Its fingertip blood spot is analyzed using DNA methylation markers, with reports covering epigenetic age, telomere length, Dunedin PACE, intrinsic and extrinsic epigenetic age, immune-cell ratios, and weight-loss response. That range makes it the most directly comparative option in this lineup for someone who wants to see more than one aging-related measure.
Compared with Aeternum, which also uses methylation but describes a more focused biological-age report, TruAge names more specific metrics and traits. It also goes further than SelfDecode and PlexusDX in the supplied description by centering its reports on methylation-based age indicators rather than broad genetic-variant findings. This distinction matters: a methylation-based estimate is not interchangeable with inherited genetic risk or a standard blood biomarker panel.
The tradeoff is collection and patience. A fingertip blood spot may be a sticking point for people who avoid needles, while Aeternum’s saliva and SelfDecode’s cheek swab may feel simpler. The stated turnaround is two to three weeks, so this is not a same-day answer. TruAge describes HIPAA-compliant handling and no third-party sharing, but buyers should still read the provider’s current privacy terms before sending sensitive biological data. I would choose it for a broad methylation snapshot, not as a medical diagnosis or a substitute for clinician-guided care.
Pros:- Reports multiple methylation-related measures, including Dunedin PACE and intrinsic and extrinsic epigenetic age.
- Fingertip blood-spot collection can be completed at home without an in-lab appointment.
- The stated two-to-three-week turnaround gives buyers a defined expectation.
- The product description states HIPAA-compliant handling and no third-party data sharing.
Cons:- Blood-spot collection may be uncomfortable or inconvenient for some buyers.
- Results take weeks, and the broad report suite may take time to interpret.
- The results should not be treated as a clinical diagnosis.
Best for: People who want several named DNA-methylation age and aging-related measures in one at-home test.
Not ideal for: People who want to avoid a blood sample, need results quickly, or expect a test to diagnose a health condition.
- Sample type:Fingertip blood spot
- Analysis:DNA methylation markers
- Named reports:Epigenetic age, telomere length, Dunedin PACE, intrinsic and extrinsic age, immune-cell ratios, and weight-loss response
- Turnaround:Two to three weeks
- Collection:At-home fingertip collection
- Data handling:HIPAA-compliant; product information states no third-party sharing
Our verdict“I rank TruAge first for buyers who want the broadest clearly named set of methylation-based aging measures in this group.”
SelfDecode Healthy Aging and Longevity At-Home DNA Test
SelfDecode Healthy Aging and Longevity is my pick for buyers who want an at-home test with no blood draw and a substantial set of practical recommendations. It uses a cheek swab to examine longevity-linked genetic variants and presents an online report with 50 personalized recommendations. The supplied description says its analysis draws on 200 million genetic variants and peer-reviewed research, with processing at a CLIA-certified lab.
Its main difference from TruAge is the kind of information it offers. TruAge reports several DNA-methylation age measures, while SelfDecode focuses on genetic variants and how they may relate to healthy aging and cellular-aging markers. A genetic profile is not the same as a current biological-age estimate, so I would choose this for genetics-led wellness context rather than the clearest methylation-clock comparison. Compared with PlexusDX, SelfDecode lists fewer recommendations but gives a specific count of 50 and describes its privacy controls in more detail.
The collection experience is a real advantage for people who do not want a blood spot: swab the cheek, use the prepaid return mailer, and view the report online. The tradeoff is that buyers must mail a sample and access results digitally; this is not an instant readout. Its educational and wellness-only status also puts a limit on how the recommendations should be used. I would not rely on it to diagnose, treat, or prevent disease, and I would not assume a recommendation is appropriate for an individual without considering medical history and clinician advice.
Pros:- Cheek-swab collection avoids a blood spot or needle.
- Includes a prepaid return mailer for sending the sample to the lab.
- The online report offers 50 personalized recommendations.
- The product description states encrypted data, deletion options, and HIPAA/GDPR alignment.
Cons:- The report is educational and wellness-focused, not a medical diagnosis or treatment plan.
- Sample return and online result access are required.
- Genetic-variant findings are not the same as a DNA-methylation biological-age measurement.
Best for: People who prefer a cheek swab and want a genetics-based healthy-aging report with personalized wellness recommendations.
Not ideal for: Buyers specifically seeking a validated methylation-age panel, a paper report, or medical diagnosis and treatment guidance.
- Sample collection:At-home cheek swab
- Laboratory:CLIA-certified lab
- Analysis:AI analysis across 200 million genetic variants and peer-reviewed research
- Report:Online report with 50 personalized recommendations
- Return shipping:Prepaid return mailer included
- Privacy:Encrypted; HIPAA/GDPR-aligned; data deletion option stated
- Intended use:Educational and wellness purposes only
Our verdict“I recommend SelfDecode when easy collection and genetics-based recommendations matter more than a broad set of methylation age metrics.”
Aeternum DNA Biological Age Test Kit
Aeternum DNA Biological Age Test Kit is the straightforward choice for a buyer who wants a saliva-based DNA-methylation estimate without the fingertip collection used by TruAge. The kit includes a saliva collection device, instructions, and a prepaid return mailer, then provides a digital biological-age report with lifestyle recommendations. That simple path makes it easier to understand what the product is for: estimate biological age from methylation markers and offer ideas for follow-up.
Compared with TruAge Complete Collection, Aeternum lists fewer distinct metrics. TruAge names several measures, including Dunedin PACE and immune-cell ratios, while Aeternum’s description centers on a biological-age estimate and recommendations. That narrower scope may suit someone who wants a focused result, but it leaves less information for buyers who want to compare different age clocks or explore trait-specific reports. It is also different from SelfDecode: Aeternum analyzes methylation markers, whereas SelfDecode’s described approach examines genetic variants.
The saliva format avoids blood collection, but it does not remove the wait: the sample still has to be mailed, and results are described as arriving in a few weeks. The kit supports repeat tracking, though a change between tests should not automatically be read as a durable health improvement; collection conditions and the test’s method matter. I would pick Aeternum for a focused, at-home methylation report, and skip it if I wanted a detailed set of named metrics, physician review, or a result that does not require digital access.
Pros:- Saliva collection avoids the fingertip blood spot used by TruAge.
- Includes instructions and a prepaid return mailer.
- Provides a digital biological-age report with lifestyle recommendations.
- The product is described as suitable for tracking biological age over time.
Cons:- The report description lists fewer separate metrics than TruAge’s report suite.
- Results take a few weeks and require mailing a saliva sample.
- The supplied product details do not specify a precise turnaround window.
Best for: First-time buyers who want a focused methylation-based age estimate and prefer saliva collection to a blood spot.
Not ideal for: People who want multiple named aging metrics, physician-reviewed interpretation, or results without mailing a sample.
- Test type:At-home DNA-methylation test
- Sample:Saliva
- Analysis:DNA methylation markers
- Laboratory:CLIA-certified labs
- Report:Digital biological-age report with lifestyle recommendations
- Turnaround:A few weeks
- Included:Saliva collection device, instructions, and prepaid return mailer
Our verdict“Aeternum is the simplest fit for a buyer who wants a saliva-based methylation estimate without the broader reporting offered by TruAge.”
Hundred Health Comprehensive Lab Test with 100+ Biomarkers
Hundred Health Comprehensive Lab Test takes a different route from the DNA tests above. Rather than describing a methylation clock or genetic-variant analysis, it measures more than 100 biomarkers tied to areas such as heart and metabolic health, hormones, inflammation, nutrients, stress, and aging. Licensed physicians review the results and provide personalized insights, while the app brings lab results, records, wearable data, and tracking together.
That clinical context is its strongest distinction from TruAge and Aeternum, which are presented as DNA-methylation age tests. Hundred Health may help a buyer see present-day health measurements related to aging, but the supplied information does not say it calculates biological age through an epigenetic clock. I would not buy it expecting the same kind of output as a DNA-methylation test. Compared with SelfDecode and PlexusDX, it is also less focused on inherited genetic traits and more oriented toward lab values and clinician-reviewed interpretation.
The app’s ability to combine health records and wearable data may appeal to someone already tracking several parts of health, and physician review offers a human layer absent from the other product descriptions. The main drawback is access: in-lab appointments are unavailable in the U.S. Virgin Islands, American Samoa, Northern Mariana Islands, Guam, North Dakota, South Dakota, West Virginia, and Hawaii. Buyers should check current eligibility and appointment details before selecting it. I see this as the best choice for broader health context, not the most direct answer to “What is my biological age?”
Pros:- Measures more than 100 biomarkers across several health areas related to aging.
- Licensed physicians review results and provide personalized insights.
- The app combines lab results, medical records, wearable data, and recommendations.
- Supports tracking biomarkers and health data over time.
Cons:- The supplied information does not describe a DNA-methylation age calculation.
- In-lab appointments are unavailable in several states and U.S. territories.
- It may be more health-data oriented than a buyer seeking one clear biological-age result needs.
Best for: People who want a broad set of lab biomarkers, physician-reviewed insights, and app-based tracking in one place.
Not ideal for: Buyers who specifically want a DNA-methylation biological-age clock or who live in a listed area without in-lab availability.
- Biomarkers:More than 100
- Health areas:Heart and metabolic health, hormones, inflammation, nutrients, stress, and aging
- App features:Combines lab results, medical records, wearable data, and recommendations
- Progress tracking:Track biomarkers and health data over time
- Appointment exclusions:U.S. Virgin Islands, American Samoa, Northern Mariana Islands, Guam, North Dakota, South Dakota, West Virginia, and Hawaii
Our verdict“I would choose Hundred Health for physician-reviewed biomarker context, not as a like-for-like replacement for an epigenetic age test.”
PlexusDx Methylation and Longevity Genetic Test
PlexusDx Methylation and Longevity Genetic Test is aimed at buyers who want a wide-ranging genetics report rather than a narrowly focused age estimate. It advertises more than 150 reports across healthy aging, longevity, methylation, and related traits, with topics including biological age, telomeres, cognition, and muscle loss. The kit uses an at-home DNA sample and includes a prepaid mailer, plus personalized diet, supplement, and lifestyle recommendations.
The sheer range is its clearest differentiator from Aeternum, whose description focuses on a digital age report, and from TruAge, which specifies a smaller set of distinct methylation-related measures. PlexusDX may appeal to someone curious about several longevity-adjacent traits, but a high report count does not by itself show how any one result is calculated or how useful it will be. In the supplied information, the test is described as analyzing more than 200 million genetic variants, yet the exact sample method, turnaround time, and detailed biological-age methodology are not specified.
That missing detail is the key tradeoff. SelfDecode also takes a genetics-led wellness approach, but it names a cheek swab, CLIA-certified processing, and a set of 50 recommendations. PlexusDX states the prepaid return mailer and broad report coverage, but gives less practical detail about collection and timing. I would consider it for breadth of longevity-related topics, then check the current kit instructions and privacy terms before purchase. I would skip it if the priority is a clearly documented methylation clock, a known results window, or clinician-reviewed interpretation.
Pros:- Lists more than 150 reports across longevity, healthy aging, methylation, and related traits.
- Includes topics such as biological age, telomeres, cognition, and muscle loss.
- Provides personalized diet, supplement, and lifestyle recommendations.
- Includes a prepaid mailer for returning the DNA sample.
Cons:- The supplied product information does not specify how long results take.
- The exact collection method and biological-age calculation are not detailed in the supplied information.
- A broad report count may produce more information than some buyers need.
Best for: People interested in a large set of genetics-related longevity and healthy-aging topics, including telomeres, cognition, and muscle loss.
Not ideal for: Buyers who need a specified turnaround time, detailed explanation of the biological-age method, or physician-reviewed results.
- Test type:At-home DNA test
- Reports:More than 150 DNA reports
- Genetic analysis:Over 200 million genetic variants
- Topics:Healthy aging, longevity, methylation, biological age, telomeres, cognition, and muscle loss
- Recommendations:Personalized diet, supplement, and lifestyle guidance
- Sample return:Prepaid return mailer
- Product dimensions:6.63 x 4.5 x 0.88 inches
- Item weight:2.08 ounces
Our verdict“PlexusDX is the broadest stated genetics-report option here, but I would choose it only if report range matters more than method and turnaround clarity.”
How We Picked
I ranked these options by how directly their stated methods relate to biological age, how much context a buyer can expect from the report, and how workable the test is to collect and repeat. A biological-age result is only useful when a buyer understands what was measured: DNA methylation, inherited genetic variation, or circulating biomarkers each describe a different slice of health and aging. I gave more weight to products that specify their approach and identify distinct measures than to a large report count by itself.
I also compared practical details that can affect follow-through: whether collection involves saliva, a cheek swab, a fingertip blood spot, or an in-lab appointment; whether return shipping is included; how long results may take; and whether the product offers useful interpretation or longitudinal tracking. Privacy details and physician involvement matter, but they do not make unlike tests directly comparable. A doctor-reviewed biomarker panel can provide helpful health context without functioning as a biological-age clock, while a wellness report can offer recommendations without serving as medical advice.
The ranking is not a claim that one biological-age method is proven best for every purpose. I treated the supplied product descriptions as the basis for comparison and avoided assuming unlisted validation, accuracy, or clinical outcomes. Each pick has a distinct role: TruAge leads for breadth of named methylation measures; SelfDecode stands out for a needle-free, genetics-led wellness report; Aeternum offers a focused saliva-based methylation option; Hundred Health is the clinical-context choice; and PlexusDX targets buyers who want many genetics-related reports. I would discuss concerning results with a qualified clinician rather than use any of these kits to diagnose or change treatment.
| biological age test | Analysis |
|---|---|
| TruAge Complete Collection | DNA methylation markers |
| SelfDecode Healthy Aging and L | AI analysis across 200 million genetic variants and peer-reviewed research |
| Aeternum DNA Biological Age Te | DNA methylation markers |
| Hundred Health Comprehensive L | — |
| PlexusDx Methylation and Longe | — |
Factors to Consider When Choosing Best Biological Age Tests
My first question is not which kit promises the most information, but what kind of information I want. A DNA-methylation test, a genetic-variant test, and a broad lab panel answer different questions. I would choose a method before comparing report length, then check sample requirements, privacy, result interpretation, and repeat-testing plans.
Know What the Test Measures
DNA methylation tests look at chemical tags on DNA and use patterns to estimate age-related measures. TruAge and Aeternum explicitly describe methylation analysis; TruAge names a wider collection of metrics, while Aeternum centers on a biological-age report. Genetic tests such as SelfDecode and PlexusDX look at variants and their possible relationships to traits. Those inherited variants can inform wellness recommendations, but they are not the same as a current methylation-age estimate. Hundred Health measures lab biomarkers, which can provide health context without being a DNA clock.
I would read the product’s method description before treating a number as a definitive measure of aging. A result labeled “biological age” is not automatically comparable with another company’s result, especially when methods, samples, and metrics differ. If comparing results over time is the goal, using the same test and method is more informative than alternating among unrelated tests.
Match Sample Collection to Your Comfort
Collection can determine whether a test is easy to complete. SelfDecode uses a cheek swab, Aeternum uses saliva, and TruAge uses a fingertip blood spot. PlexusDX is described as an at-home DNA test with a prepaid return mailer, but the supplied details do not specify the exact collection method. Hundred Health involves lab testing and an in-lab appointment, with regional availability exclusions.
Every mail-in DNA test still involves packaging and returning a sample, even when the collection itself is simple. If blood collection is a barrier, the cheek-swab or saliva options may suit you better. If an appointment is inconvenient or unavailable where you live, check access before choosing Hundred Health.
Compare What the Reports Actually Tell You
More reports do not necessarily mean a clearer answer. TruAge names multiple age-related measures, including Dunedin PACE, telomere length, and intrinsic and extrinsic epigenetic age. SelfDecode gives a specific count of 50 personalized recommendations, while PlexusDX lists more than 150 reports across a broader range of longevity topics. Aeternum describes a focused biological-age report, and Hundred Health offers more than 100 biomarkers with physician-reviewed insights.
I would ask whether a report gives a metric I can interpret, whether it explains its limits, and whether the recommendations fit the kind of result being measured. A long list of traits is not a substitute for a clear explanation. Physician review may help with lab results, but it does not make a product a dedicated biological-age test if its stated method is biomarker measurement rather than an age clock.
Think About Follow-Up and Turnaround
Biological age is often most appealing as something to track, but a single result is only a snapshot. Aeternum is described as suitable for tracking over time, and Hundred Health supports biomarker and health-data tracking. TruAge states a two-to-three-week turnaround; Aeternum says a few weeks. The supplied descriptions do not state an exact results window for SelfDecode or PlexusDX.
For a repeat test, I would use the same service and follow its collection instructions carefully. I would also avoid interpreting a small shift as proof that a lifestyle change caused a lasting difference. Ask the provider how its measurements should be compared across time, and speak with a clinician if results raise health concerns.
Read Privacy and Medical-Use Limits
DNA and health data are sensitive. The product descriptions state different protections: SelfDecode lists encryption, HIPAA/GDPR alignment, and a data deletion option; TruAge states HIPAA-compliant handling and no third-party sharing. I would still review each provider’s current privacy policy for storage, sharing, retention, deletion, and research use rather than relying on a short product summary.
These kits should not replace medical advice. SelfDecode explicitly describes its test as educational and for wellness use, not diagnosis, treatment, cure, or prevention. For any test, I would bring results to a qualified clinician before making medical decisions, changing medication, or starting supplements based on a report.
Frequently Asked Questions
What is a biological age test measuring?
A biological-age test estimates aging-related information from a selected set of measurements, but the method varies. TruAge and Aeternum describe DNA-methylation analysis; SelfDecode and PlexusDX describe genetics-based reports; Hundred Health measures a broad set of lab biomarkers. These approaches do not produce interchangeable results. I would check the method and the exact metrics before comparing numbers across providers.
Are methylation tests better than genetic tests for biological age?
They answer different questions rather than competing as identical tools. Methylation tests estimate age-related measures from DNA methylation patterns, while genetic reports focus on inherited variants and possible trait relationships. In this lineup, TruAge and Aeternum describe methylation methods, while SelfDecode and PlexusDX emphasize genetic analysis. I would choose based on whether I want an age-related methylation estimate or broader genetics-led wellness information.
Can I use a biological-age result to diagnose a condition?
No. These product descriptions do not establish that the tests can diagnose disease. SelfDecode specifically says its report is for educational and wellness purposes, not diagnosis or treatment. Hundred Health includes physician-reviewed biomarker insights, but a lab panel still needs to be interpreted in clinical context. I would discuss concerning results with a qualified healthcare professional rather than self-diagnose or alter treatment.
How should I compare results from two different tests?
I would avoid treating results from different providers or methods as directly comparable. A methylation age estimate, genetic-variant report, and biomarker panel measure different things and may use different calculations. For tracking change, using the same test and following its collection instructions each time gives a more consistent basis for comparison. Even then, a change in a result does not by itself prove a change in overall health or lifespan.
Which test is easiest to collect at home?
Among the products with a specified collection method, SelfDecode uses a cheek swab, Aeternum uses saliva, and TruAge uses a fingertip blood spot. The first two avoid a blood sample, while TruAge offers more named methylation metrics. PlexusDX describes an at-home DNA test but does not specify the exact collection method in the supplied information. All mail-in options require returning a sample and waiting for results.
Conclusion
For the buyer whose priority is a broad set of clearly named epigenetic measures, I recommend TruAge Complete Collection. Choose SelfDecode if you prefer a cheek swab and want genetics-based wellness recommendations, or Aeternum if a saliva-based, focused methylation report feels like a better first step. Hundred Health makes more sense for people who want physician-reviewed biomarker context and app-based health tracking, not a dedicated DNA clock. PlexusDX suits buyers drawn to a wide range of longevity-related reports who are comfortable with the missing detail around turnaround and the exact age calculation.
Before ordering, I would decide whether I want an age estimate, genetics-led recommendations, or a broader view of current biomarkers. I would also check sample requirements, local appointment access where relevant, privacy terms, and how the provider explains its results. No kit here can replace medical care, and no single biological-age number should be treated as a verdict on a person’s health.
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